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Int J Clin Exp Pathol. 2015 May 1;8(5):5681-7. eCollection 2015.

No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population.

Author information

1
Department of Neurosurgery, Shanghai Neurosurgical Center, Huashan Hospital, Fudan University Shanghai, China.
2
State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University Shanghai, PR China.

Abstract

Vesicle-associated membrane protein 8 (VAMP8) gene plays an important role in biological functions like endosomal fusion, sequential granule-to-granule fusion and autophagy. The current research identified VAMP8 acted as a novel oncogene by promoting cell proliferation and therapeutic resistance in glioma. Nevertheless, the association between VAMP8 genes polymorphism and glioma patients has not been well studied. In our study, to explore the association between single nucleotide polymorphisms (SNPs) of VAMP8 gene with glioma risk in the Chinese Han population, we performed a hospital based case-control study (992 cases and 1008 controls). Eight common tagging SNPs of VAMP8 gene were genotyped, while no significant difference in allele or genotype frequency was found between glioma patients and healthy controls. No positive linkage disequilibrium (LD) was detected either. No haplotype distribution was positive. Accordingly, our study suggested that VAMP8 gene variants might not contribute to glioma susceptibility and associated with glioma in the Chinese Han population.

KEYWORDS:

VAMP8 gene; genetic susceptibility; glioma; molecular biology; polymorphisms

PMID:
26191281
PMCID:
PMC4503152
[Indexed for MEDLINE]
Free PMC Article

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