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Int J Clin Exp Pathol. 2015 May 1;8(5):5519-27. eCollection 2015.

LAMP3 and TP53 overexpression predicts poor outcome in laryngeal squamous cell carcinoma.

Author information

1
Department of Otorhinolaryngology/Head and Neck Surgery, Nantong University Affiliated Hospital Jiangsu 226001, China.
2
Department of Pathology, Nantong University Affiliated Hospital Jiangsu 226001, China.
3
Department of Laboratory Medicine, Nantong University Affiliated Hospital Jiangsu 226001, China.
4
Department of General Surgery, Nantong University Affiliated Hospital Jiangsu 226001, China.

Abstract

Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific and hypoxia-induced protein. It is a downstream target gene of tumor suppressor TP53 and its expression has been associated with hypoxia-induced metastasis and poor overall survival in cervical, breast and gastrointestinal cancers. However, little is known of LAMP3 protein expression in laryngeal squamous cell carcinoma (LSCC) and its prognostic value. We determined protein expression of LAMP3 and TP53 in LSCC tissues (n=117) by immunohistochemistry analysis on tissue microarray (TMA), their expression was correlated with patients' clinical parameters and overall survival. LAMP3 and TP53 protein expression was significantly higher in cancerous tissues compared to adjacent normal surgical margin tissues. Both high LAMP3 and high TP53 protein expression was significantly associated with tumor stage and size. Significant correlation between LAMP3 and TP53 expression was observed. Patients with high LAMP3 or high TP53 expression had a poor overall survival. Our data suggest that both epithelial LAMP3 expression and TP53 expression are independent prognostic markers for LSCC.

KEYWORDS:

LAMP3; TP53; laryngeal squamous cell carcinoma; prognosis

PMID:
26191259
PMCID:
PMC4503130
[Indexed for MEDLINE]
Free PMC Article

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