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Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10596-9. doi: 10.1002/anie.201503562. Epub 2015 Jul 17.

Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols.

Author information

1
Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de.
2
Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a, 18059 Rostock (Germany) http://www.catalysis.de. matthias.beller@catalysis.de.

Abstract

The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.

KEYWORDS:

alcohols; carboxylic acids; homogeneous catalysis; hydrogenation; ruthenium

PMID:
26190772
DOI:
10.1002/anie.201503562

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