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Curr Opin Plant Biol. 2015 Oct;27:111-7. doi: 10.1016/j.pbi.2015.06.013. Epub 2015 Jul 17.

Antiviral roles of plant ARGONAUTES.

Author information

1
Donald Danforth Plant Science Center, St. Louis, MO 63132, USA. Electronic address: acarbonell@ibmcp.upv.es.
2
Donald Danforth Plant Science Center, St. Louis, MO 63132, USA.

Abstract

ARGONAUTES (AGOs) are the effector proteins functioning in eukaryotic RNA silencing pathways. AGOs associate with small RNAs and are programmed to target complementary RNA or DNA. Plant viruses induce a potent and specific antiviral RNA silencing host response in which AGOs play a central role. Antiviral AGOs associate with virus-derived small RNAs to repress complementary viral RNAs or DNAs, or with endogenous small RNAs to regulate host gene expression and promote antiviral defense. Here, we review recent progress towards understanding the roles of plant AGOs in antiviral defense. We also discuss the strategies that viruses have evolved to modulate, attenuate or suppress AGO antiviral functions.

PMID:
26190744
PMCID:
PMC4618181
DOI:
10.1016/j.pbi.2015.06.013
[Indexed for MEDLINE]
Free PMC Article

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