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Cell Metab. 2015 Sep 1;22(3):381-97. doi: 10.1016/j.cmet.2015.06.010. Epub 2015 Jul 16.

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.

Author information

1
Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Broad Institute of Harvard and MIT, Boston, MA 02115, USA.
2
Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Broad Institute of Harvard and MIT, Boston, MA 02115, USA. Electronic address: ghotamis@hsph.harvard.edu.

Abstract

A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest threat to human health. As research in this field has advanced, it has become clear that unresolved metabolic inflammation, organelle dysfunction, and other cellular and metabolic stresses underlie the development of these chronic metabolic diseases. However, the relationship between these systems and pathological mechanisms is poorly understood. Here we discuss the role of cellular Ca(2+) homeostasis as a critical mechanism integrating the myriad of cellular and subcellular dysfunctional networks found in metabolic tissues such as liver and adipose tissue in the context of metabolic disease, particularly in obesity and diabetes.

PMID:
26190652
PMCID:
PMC4558313
DOI:
10.1016/j.cmet.2015.06.010
[Indexed for MEDLINE]
Free PMC Article

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