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Alzheimers Dement. 2015 Sep;11(9):1023-31. doi: 10.1016/j.jalz.2015.06.1888. Epub 2015 Jul 17.

Mediterranean diet and preserved brain structural connectivity in older subjects.

Author information

1
Univ. Bordeaux, ISPED, Centre INSERM U897, F-33076 Bordeaux, France; INSERM, ISPED, Centre INSERM U897, F-33076 Bordeaux, France.
2
Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR 5287, F-33076 Bordeaux, France.
3
Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR 5287, F-33076 Bordeaux, France; CHU de Bordeaux, F-33076 Bordeaux, France.
4
Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR 5287, F-33076 Bordeaux, France; CHU de Bordeaux, F-33076 Bordeaux, France; EPHE, Laboratoire Neurobiologie Intégrative et Adaptative, F-33076 Bordeaux, France.
5
Univ. Bordeaux, INCIA, UMR 5287, F-33076 Bordeaux, France; CNRS, INCIA, UMR 5287, F-33076 Bordeaux, France; EPHE, Laboratoire Neurobiologie Intégrative et Adaptative, F-33076 Bordeaux, France.
6
Univ. Bordeaux, ISPED, Centre INSERM U897, F-33076 Bordeaux, France; INSERM, ISPED, Centre INSERM U897, F-33076 Bordeaux, France. Electronic address: Cecilia.Samieri@isped.u-bordeaux2.fr.

Abstract

INTRODUCTION:

The Mediterranean diet (MeDi) has been related to a lower risk of Alzheimer's disease; yet, the underlying mechanisms are unknown. We hypothesized that protection against neurodegeneration would translate into higher gray matter volumes, whereas a specific association with preserved white matter microstructure would suggest alternative mechanisms (e.g., vascular pathways).

METHODS:

We included 146 participants from the Bordeaux Three-City study nondemented when they completed a dietary questionnaire and who underwent a 3-T magnetic resonance imaging at an average of 9 years later, including diffusion tensor imaging.

RESULTS:

In multivariate voxel-by-voxel analyses, adherence to the MeDi was significantly associated with preserved white matter microstructure in extensive areas, a gain in structural connectivity that was related to strong cognitive benefits. In contrast, we found no relation with gray matter volumes.

DISCUSSION:

The MeDi appears to benefit brain health through preservation of structural connectivity. Potential mediation by a favorable impact on brain vasculature deserves further research.

KEYWORDS:

Diffusion tensor imaging; Mediterranean diet; Neuroimaging; Prospective studies; Risk factors in epidemiology; Voxel-based morphometry

PMID:
26190494
DOI:
10.1016/j.jalz.2015.06.1888
[Indexed for MEDLINE]

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