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J Biosci Bioeng. 2015 Dec;120(6):666-9. doi: 10.1016/j.jbiosc.2015.04.011. Epub 2015 Jul 15.

Finding of thiosulfate pathway for synthesis of organic sulfur compounds in Saccharomyces cerevisiae and improvement of ethanol production.

Author information

1
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan.
2
Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.
3
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan. Electronic address: iohtsu@bs.naist.jp.
4
Technical Research Laboratories, Kyowa Hakko Bio Co. Ltd., 1-1 Kyowa-cho, Hofu, Yamaguchi 747-8522, Japan.
5
MS Business Unit, Shimadzu Co., 1 Nishinokyo, Kuwabara-cho, Nakagyo-ku, Kyoto 604-8511, Japan.

Abstract

We found that Saccharomyces cerevisiae utilizes thiosulfate as a sole sulfur source. The energetically-favored thiosulfate rather than sulfate as sulfur sources is also more effective for improving growth and ethanol-production rate in S. cerevisiae due to high levels of intracellular NADPH during thiosulfate utilization.

KEYWORDS:

Ethanol production; Pentose phoshate pathway; Saccharomyces cerevisiae; Sulfur metabolism; Sulfur metabolome; Thiosulfate assimilation

PMID:
26188417
DOI:
10.1016/j.jbiosc.2015.04.011
[Indexed for MEDLINE]

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