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Cancer Lett. 2015 Oct 10;367(1):18-25. doi: 10.1016/j.canlet.2015.07.008. Epub 2015 Jul 14.

Reactive oxygen species in redox cancer therapy.

Author information

1
Edison Biotechnology Institute, Konneker Research Center, Ohio University, Athens, OH 45701, USA.
2
Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
3
Edison Biotechnology Institute, Konneker Research Center, Ohio University, Athens, OH 45701, USA; Department of Chemistry and Biochemistry, Molecular and Cellular Biology Program, Ohio University, Athens, OH 45701, USA. Electronic address: wus1@ohio.edu.
4
Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: zuo.4@osu.edu.

Abstract

The role of reactive oxygen species (ROS) in cancer cells has been intensively studied for the past two decades. Cancer cells mostly have higher basal ROS levels than their normal counterparts. The induction of ROS has been shown to be associated with cancer development, metastasis, progression, and survival. Various therapeutic approaches targeting intracellular ROS levels have yielded mixed results. As widely accepted dietary supplements, antioxidants demonstrate both ROS scavenging ability and anti-cancer characteristics. However, antioxidants may not always be safe to use since excessive intake of antioxidants could lead to serious health concerns. In this review, we have evaluated the production and scavenging systems of ROS in cells, as well as the beneficial and harmful roles of ROS in cancer cells. We also examine the effect of antioxidants in cancer treatment, the effect of combined treatment of antioxidants with traditional cancer therapies, and the side effects of excessive antioxidant intake.

KEYWORDS:

Antioxidant; Cancer therapy; Oxidative stress; Redox; Tumor

PMID:
26187782
DOI:
10.1016/j.canlet.2015.07.008
[Indexed for MEDLINE]

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