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Am J Mens Health. 2017 Jul;11(4):1124-1129. doi: 10.1177/1557988315595693. Epub 2015 Jul 17.

Precision Medicine and Men's Health.

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1 Harvard Medical School, Boston, MA, USA.
2 Weill Cornell Medical College, New York, NY, USA.
3 Baylor College of Medicine, Houston, TX, USA.


Precision medicine can greatly benefit men's health by helping to prevent, diagnose, and treat prostate cancer, benign prostatic hyperplasia, infertility, hypogonadism, and erectile dysfunction. For example, precision medicine can facilitate the selection of men at high risk for prostate cancer for targeted prostate-specific antigen screening and chemoprevention administration, as well as assist in identifying men who are resistant to medical therapy for prostatic hyperplasia, who may instead require surgery. Precision medicine-trained clinicians can also let couples know whether their specific cause of infertility should be bypassed by sperm extraction and in vitro fertilization to prevent abnormalities in their offspring. Though precision medicine's role in the management of hypogonadism has yet to be defined, it could be used to identify biomarkers associated with individual patients' responses to treatment so that appropriate therapy can be prescribed. Last, precision medicine can improve erectile dysfunction treatment by identifying genetic polymorphisms that regulate response to medical therapies and by aiding in the selection of patients for further cardiovascular disease screening.


andrology; biologic determinants of health; genetics; health screening; physiological and endocrine disorders

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