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Expert Rev Proteomics. 2015 Aug;12(4):425-32. doi: 10.1586/14789450.2015.1055324.

The human urinary exosome as a potential metabolic effector cargo.

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Laboratory on Pathophysiology of Uremia Istituto Giannina Gaslini, Via V Maggio 39, 16148 Genova, Italy.


Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells can rescue bioenergetics of injured cells. Here the urinary exosome proteome, non-urinary exosome proteome and urinome are compared. A consistent number of identified proteins cluster to metabolic functions. Cytoscape software analysis based on biological processes gene ontology database shows that metabolic pathways such as aerobic glycolysis and oxidative phosphorylation have a high probability (p ≤ 0.05) of being expressed and therefore functional. A metabolic function appears to be associated with human urinary exosomes, whose relevance experimental studies can assess.


FoF1-ATP synthase; exosome; mass spectrometry; oxidative phosphorylation; proteomics; respiratory complexes; urinome

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