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Mol Cell. 2015 Jul 16;59(2):146-8. doi: 10.1016/j.molcel.2015.07.002.

Putting Non-coding RNA on Display with CRISPR.

Author information

1
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
2
Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
3
Department of Electrical Engineering and Computer Science, Department of Biological Engineering, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: timlu@mit.edu.

Abstract

In a recent issue of Nature Methods, Shechner et al. (2015) reported the development of CRISPR Display (CRISP-Disp), which is a sophisticated, flexible, modular, and multiplexable platform for targeting different types of non-coding RNAs (ncRNAs) to genomic loci. CRISP-Disp will facilitate synthetic-biology applications and enable the elucidation of ncRNA functions.

PMID:
26186289
DOI:
10.1016/j.molcel.2015.07.002
[Indexed for MEDLINE]
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