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Cell. 2015 Jul 16;162(2):456-456.e1. doi: 10.1016/j.cell.2015.06.061.

SnapShot: Spliceosome Dynamics II.

Author information

1
Laboratory of Structural Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.
2
Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

Abstract

Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to regulate splicing. The majority of higher eukaryotic protein-coding genes contain more than one intron and the derived pre-mRNAs can be alternatively spliced. Diverse principles ensure the reliable identification of authentic splice sites while concomitantly providing flexibility in splice site choice during alternative splicing. Some species contain a second type of minor (U12-type) spliceosome.

PMID:
26186196
DOI:
10.1016/j.cell.2015.06.061
[Indexed for MEDLINE]
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