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J Neuropsychiatry Clin Neurosci. 2015 Fall;27(4):345-53. doi: 10.1176/appi.neuropsych.14120387. Epub 2015 Jul 17.

Neural Correlates of Intolerance of Uncertainty in Clinical Disorders.

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From the University Medical Center Utrecht, Image Sciences Institute, Utrecht, Netherlands (MW, PS); Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, Netherlands (PS), and the Dept. of Clinical and Health Psychology, Utrecht University, Utrecht, Netherlands (LS).


Intolerance of uncertainty is a key contributor to anxiety-related disorders. Recent studies highlight its importance in other clinical disorders. The link between its clinical presentation and the underlying neural correlates remains unclear. This review summarizes the emerging literature on the neural correlates of intolerance of uncertainty. In conclusion, studies focusing on the neural correlates of this construct are sparse, and findings are inconsistent across disorders. Future research should identify neural correlates of intolerance of uncertainty in more detail. This may unravel the neurobiology of a wide variety of clinical disorders and pave the way for novel therapeutic targets.

[Indexed for MEDLINE]

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