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FEBS J. 2015 Oct;282(19):3669-80. doi: 10.1111/febs.13378. Epub 2015 Jul 31.

Mapping the SUMOylated landscape.

Author information

1
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

SUMOylation is a post-translational modification that regulates a multitude of cellular processes, including replication, cell-cycle progression, protein transport and the DNA damage response. Similar to ubiquitin, SUMO (small ubiquitin-like modifier) is covalently attached to target proteins in a reversible process via an enzymatic cascade. SUMOylation is essential for nearly all eukaryotic organisms, and deregulation of the SUMO system is associated with human diseases such as cancer and neurodegenerative diseases. Therefore, it is of great interest to understand the regulation and dynamics of this post-translational modification. Within the last decade, mass spectrometry analyses of SUMO proteomes have overcome several obstacles, greatly expanding the number of known SUMO target proteins. In this review, we briefly outline the basic concepts of the SUMO system, and discuss the potential of proteomic approaches to decipher SUMOylation patterns in order to understand the role of SUMO in health and disease.

KEYWORDS:

SUMO; cross-talk; group modification; mass spectrometry; post-translational modification; proteomics; site-specific; small ubiquitin-like modifier; ubiquitin

PMID:
26185901
PMCID:
PMC4869838
DOI:
10.1111/febs.13378
[Indexed for MEDLINE]
Free PMC Article

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