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J Pediatric Infect Dis Soc. 2015 Jun;4(2):e17-21. doi: 10.1093/jpids/piu054. Epub 2014 Jun 12.

Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.

Author information

1
Department of Paediatric Infectious Diseases ; Section of Paediatrics, Imperial College, London, United Kingdom.
2
Paediatric Neurodisability Service, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
3
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom.
4
Children's Neurosciences, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
5
Department of Paediatric Neurology, St George's Hospital, St George's Hospital NHS Trust, London, United Kingdom.
6
Section of Paediatrics, Imperial College, London, United Kingdom.
7
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom ; Children's Neurosciences, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Abstract

N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.

KEYWORDS:

HSV; NMDAR; encephalitis; pediatric; plasmapheresis

PMID:
26185621
PMCID:
PMC4501512
DOI:
10.1093/jpids/piu054
[Indexed for MEDLINE]
Free PMC Article

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