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Toxins (Basel). 2015 Jul 14;7(7):2615-28. doi: 10.3390/toxins7072615.

Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins.

Author information

1
Department of Neurology, Yale University, 20 York St., New Haven, CT 06510, USA. Sara.Schaefer@yale.edu.
2
Department of Neurology, Yale University, 20 York St., New Haven, CT 06510, USA. Chris.Gottschalk@yale.edu.
3
Department of Neurology, Yale University, 20 York St., New Haven, CT 06510, USA. Bahman.Jabbari@yale.edu.

Abstract

Migraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but treatment of chronic migraine has been revolutionized with the introduction of botulinum toxin injection therapy. In this review, we explore the current understanding of migraine pathophysiology, and the evolution of the use of botulinum toxin therapy including proposed pathophysiological mechanisms through animal data. We also discuss the similarities and differences between three injection techniques.

KEYWORDS:

botulinum toxin; chronic daily headache; chronic migraine; headache; medication overuse headache; migraine; neurotoxins

PMID:
26184313
PMCID:
PMC4516932
DOI:
10.3390/toxins7072615
[Indexed for MEDLINE]
Free PMC Article

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