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Neuron. 2015 Jul 15;87(2):252-6. doi: 10.1016/j.neuron.2015.06.036.

BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images.

Author information

1
Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: hanchuanp@alleninstitute.org.
2
Allen Institute for Brain Science, Seattle, WA 98103, USA. Electronic address: mikeh@alleninstitute.org.
3
Allen Institute for Brain Science, Seattle, WA 98103, USA.
4
Center for Brain Simulation, Campus Biotech, Chemin des Mines, 9, 1202 Geneva, Switzerland.
5
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
6
Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, the Netherlands.
7
Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA. Electronic address: ascoli@gmu.edu.

Abstract

Understanding the structure of single neurons is critical for understanding how they function within neural circuits. BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recognized need for openness and standardization to provide a community resource for automated reconstruction of dendritic and axonal morphology of single neurons.

PMID:
26182412
PMCID:
PMC4725298
DOI:
10.1016/j.neuron.2015.06.036
[Indexed for MEDLINE]
Free PMC Article

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