Format

Send to

Choose Destination
PLoS Pathog. 2015 Jul 16;11(7):e1005034. doi: 10.1371/journal.ppat.1005034. eCollection 2015 Jul.

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.

Author information

1
Department of Zoology, University of Oxford, Oxford, United Kingdom.
2
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.

Abstract

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.

PMID:
26181911
PMCID:
PMC4504489
DOI:
10.1371/journal.ppat.1005034
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center