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J Atten Disord. 2015 Jul 15. pii: 1087054715593633. [Epub ahead of print]

The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.

Author information

1
University of Utah, Salt Lake City, UT, USA erin.mcglade@hsc.utah.edu.
2
University of Utah, Salt Lake City, UT, USA.
3
KYOWA HAKKO BIO CO., LTD, Tsukuba, Ibaraki, Japan.
4
KYOWA HAKKO U.S.A., INC., New York, NY, USA.

Abstract

OBJECTIVE:

This study assessed the effects of citicoline, a nutraceutical, on attention, psychomotor function, and impulsivity in healthy adolescent males.

METHOD:

Seventy-five healthy adolescent males were randomly assigned to either the citicoline group (n = 51 with 250 or 500 mg citicoline) or placebo (n = 24). Participants completed the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II) at baseline and after 28 days of supplementation.

RESULTS:

Individuals receiving citicoline exhibited improved attention (p = 0.02) and increased psychomotor speed (p = 0.03) compared with those receiving placebo. Higher weight-adjusted dose significantly predicted increased accuracy on an attention task (p = 0.01), improved signal detectability on a computerized attention task (p = 0.03), and decreased impulsivity (p = 0.01).

DISCUSSION:

Adolescent males receiving 28 days of Cognizin® citicoline showed improved attention and psychomotor speed and reduced impulsivity compared to adolescent males who received placebo.

KEYWORDS:

adolescents; citicoline; cognition; cognitive enhancement

PMID:
26179181
DOI:
10.1177/1087054715593633

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