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Aging Clin Exp Res. 2016 Apr;28(2):197-205. doi: 10.1007/s40520-015-0412-6. Epub 2015 Jul 16.

Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial.

Author information

1
Center for Preventive Medical Sciences, Chiba University, 1-8-1 Inohana, Chuo Ward, Chiba City, Chiba, 260-8670, Japan. tsuji.t@chiba-u.jp.
2
Doctoral Program in Physical Education, Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki, 305-8574, Japan.
3
Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki, 305-8574, Japan.

Abstract

BACKGROUND:

There was no evidence of satisfying the standard to decide the efficacies of glucosamine and chondroitin in middle-aged and older Japanese adults with knee pain and/or stiffness.

AIM:

To investigate the effects of 24 week oral N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain, self-reported knee function, physical activity, and physical performance.

METHODS:

We randomly assigned 11 men and 39 women (aged 52-87 years) to receive 100 mg of N-acetyl glucosamine and 180 mg of chondroitin sulfate daily (Glu/Cho group) or a placebo (control, C group) for 24 weeks. The primary outcomes were a 100 mm visual analog pain scale (VAS) and the Japanese Knee Osteoarthritis Measure (JKOM) score. The secondary outcomes were physical activity and physical performance.

RESULTS:

We observed a significant group × time interaction on the JKOM score. According to the post hoc test, it significantly decreased (i.e., improved knee function) from the 4- to 12-week follow-up in the Glu/Cho group and the Glu/Cho group score was significantly lower than the C group at the 12-week follow-up. We found a significant interaction on household physical activity. There was no significant interaction on VAS or physical performance tests.

DISCUSSION:

The results of the present study were consistent with previous studies mainly conducted in European and American countries.

CONCLUSION:

These results suggest that consumption of N-acetyl glucosamine and chondroitin sulfate for 12 weeks or longer has a positive effect on self-reported knee function and household physical activity in middle-aged and older Japanese adults with knee pain and/or stiffness.

KEYWORDS:

Japanese knee osteoarthritis measure; Knee osteoarthritis; Physical activity; Physical performance

PMID:
26178634
DOI:
10.1007/s40520-015-0412-6
[Indexed for MEDLINE]

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