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J Orthop Res. 2016 Jan;34(1):65-71. doi: 10.1002/jor.22979. Epub 2015 Jul 31.

Local delivery of zoledronate from a poly (D,L-lactide)-Coating increases fixation of press-fit implants.

Author information

1
Department of Orthopaedics, Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
2
Orthopaedic Biomechanics Laboratory, Minneapolis Medical Research Foundation and University of Minnesota, Minneapolis, Minnesota.
3
Sporthopaedicum Regensburg, Regensburg, Germany.

Abstract

Early secure fixation of total joint replacements is crucial for long-term survival. Antiresorptive agents such as bisphosphonates have been shown to increase implant fixation. We investigated whether local delivery of zoledronate from poly-D, L-lactide (PDLLA)-coated implants could improve implant fixation and osseointegration. Experimental titanium implants were bilaterally inserted press-fit into the proximal tibiae of 10 dogs. On one side the implant was coated with PDLLA containing zoledronate. The contralateral implant was uncoated and used as control. Observation period was 12 weeks. Implant fixation was evaluated with histomorphometry and biomechanical push-out test. We found an approximately twofold increase in all biomechanical parameters when comparing data from the zoledronate group with their respective controls. Histomorphometry showed increased amount of preserved bone and increased bone formation around the zoledronate implants. This study indicates that local delivery of zoledronate from a PDDLA coating has the potential to increase implant fixation.

KEYWORDS:

PDDLA; bisphosphonate; implant fixation

PMID:
26177742
PMCID:
PMC6326075
DOI:
10.1002/jor.22979
[Indexed for MEDLINE]
Free PMC Article

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