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Rev Med Inst Mex Seguro Soc. 2015 Jul-Aug;53(4):512-7.

[Correlation between the use of sodium bicarbonate and intraventricular hemorrhage in preterms].

[Article in Spanish; Abstract available in Spanish from the publisher]

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Servicio de Neonatología, División de Pediatría, Hospital Español de México, Distrito Federal, México.


in English, Spanish


Being born preterm implies comorbidities, among them the risk of intraventricular hemorrhage (IVH). The use of sodium bicarbonate has been linked to the presence of IVH. The main purpose of this study was to determine if the infusion of sodium bicarbonate during the first 24 hours increases the risk of IVH in preterm infants.


Our study is a cohort; we analyzed the files of 160 patients and divided them into two groups: one in which sodium bicarbonate was not used and another in which it was; this latter group was subdivided into two considering if the use was therapeutic of prophylactic.


In our total group of patients 10 % presented IVH; had a mean weight of 1500 g and 31 weeks of gestational age. The incidence of IVH was identical between both groups, although patients in which bicarbonate was used were more premature, unstable, and in worse clinical conditions.


Our data indicate the need of large scale studies to determine if the clinical benefits of the use of sodium bicarbonate outweigh the risk of IVH.


Hemorrhage; Premature infant; Sodium bicarbonate

[Indexed for MEDLINE]

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