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Tissue Eng Part A. 2015 Oct;21(19-20):2526-35. doi: 10.1089/ten.TEA.2014.0649. Epub 2015 Aug 24.

A Rodent Model to Evaluate the Tissue Response to a Biological Scaffold When Adjacent to a Synthetic Material.

Dearth CL1,2,3, Keane TJ1,4, Scott JR5,6, Daly KA1,2, Badylak SF1,2,4.

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1 McGowan Institute for Regenerative Medicine , Pittsburgh, Pennsylvania.
2 Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
3 DoD-VA Extremity Trauma and Amputation Center of Excellence, Walter Reed National Military Medical Center , Bethesda, Maryland.
4 Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania.
5 Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University , Providence, Rhode Island.
6 C.R. Bard, Inc. (Davol) , Providence, Rhode Island.


The use of biologic scaffold materials adjacent to synthetic meshes is commonplace. A prevalent clinical example is two-staged breast reconstruction, where biologic scaffolds are used to provide support and coverage for the inferior aspect of the synthetic expander. However, limited data exist regarding either the kinetics of biologic scaffold integration or the host tissue response to the biologic scaffold materials used for this application or other applications in which such scaffold materials are used. The present study evaluated the temporal host response to a biological scaffold when placed adjacent to a synthetic material. Evaluation criteria included quantification of material contracture and characterization of the host cell response and tissue remodeling events. Results show a decreased thickness of the collagenous tissue layer at biologic scaffold/silicone interface compared to the abdominal wall/silicone interface during the 12-week experimental time course. All test materials were readily incorporated into surrounding host tissue.

[Indexed for MEDLINE]

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