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Cancer Biol Ther. 2015;16(9):1407-14. doi: 10.1080/15384047.2015.1070990.

Salvianolic acid A reverses the paclitaxel resistance and inhibits the migration and invasion abilities of human breast cancer cells by inactivating transgelin 2.

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a Department of Pharmacy ; The First Affiliated Hospital of Xi'an Jiaotong University ; Xi'an , Shaanxi , PR China.
b Department of Pharmacy ; The People's Hospital of Bayingol Mongolian Autonomous Prefecture ; Korla , Xinjiang , PR China.
c School of Pharmacy; Xi'an Jiaotong University ; Xi'an , Shaanxi , PR China.


Multidrug resistance and tumor migration and invasion are the major obstacles to effective breast cancer chemotherapy, but the underlying molecular mechanisms remain unclear. This study investigated the potential of transgelin 2 and salvianolic acid A to modulate the resistance and the migration and invasion abilities of paclitaxel-resistant human breast cancer cells (MCF-7/PTX). MCF-7/PTX cells were found to exhibit not only a high degree of resistance to paclitaxel, but also strong migration and invasion abilities. Small interfering RNA-mediated knockdown of TAGLN2 sensitized the MCF-7/PTX cells to paclitaxel, and inhibited their migration and invasion abilities. In addition, we also observed that combined salvianolic acid A and paclitaxel treatment could reverse paclitaxel resistance, markedly inhibit tumor migration and invasion, and suppress the expression of transgelin 2 in MCF-7/PTX cells. These findings indicate that salvianolic acid A can reverse the paclitaxel resistance and inhibit the migration and invasion abilities of human breast cancer cells by down-regulating the expression of transgelin 2, and hence could be useful in breast cancer treatments.


breast cancer; invasion; migration; paclitaxel resistance; salvianolic acid A; transgelin 2

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