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Hum Vaccin Immunother. 2015;11(10):2345-9. doi: 10.1080/21645515.2015.1062955.

Do vitamin D levels affect antibody titers produced in response to HPV vaccine?

Author information

1
a Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.

Abstract

In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18-25 years were measured at baseline, and HPV antibody titers were measured one month following the third quadrivalent HPV vaccine dose. Vitamin D levels were ≥ 30 ng/ml (normal) in 60 males and <30 ng/ml (low) in 113 males. Reverse cumulative distribution curves and scatter plots showed higher antibody titers with low vitamin D for all vaccine strains (P < 0.05). In linear regression analyses, antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants (P < 0.05). These relationships add to the body of knowledge of the complex role of vitamin D in immunoregulation.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01184079.

KEYWORDS:

HPV vaccine; human papillomavirus; immunogenicity; immunoregulation; vitamin D

PMID:
26176493
PMCID:
PMC4635898
DOI:
10.1080/21645515.2015.1062955
[Indexed for MEDLINE]
Free PMC Article

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