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Cancer Cell. 2015 Jul 13;28(1):9-11. doi: 10.1016/j.ccell.2015.06.014.

Genetic Classification of Gliomas: Refining Histopathology.

Author information

1
The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA; The Ludwig Center for Cancer Genetics and Therapeutic at Johns Hopkins, Baltimore, MD 21287, USA.
2
The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA; The Ludwig Center for Cancer Genetics and Therapeutic at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address: ldiaz1@jhmi.edu.

Abstract

Newly published studies validate prior reports that specific combinations of genetic alternations in IDH1/2, ATRX, TERT, TP53, and co-deletion of 1p/19q have the ability to reclassify gliomas into rational subsets, defining a glioma's biological and clinical behavior more accurately than stratifications based solely on histopathology.

PMID:
26175411
DOI:
10.1016/j.ccell.2015.06.014
[Indexed for MEDLINE]
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