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Nat Rev Neurosci. 2015 Aug;16(8):445-57. doi: 10.1038/nrn3921. Epub 2015 Jul 15.

Development and functions of the choroid plexus-cerebrospinal fluid system.

Author information

1
1] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [2] Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
2
Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, Irvine, California 92697, USA.
3
Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Abstract

The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP-CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.

PMID:
26174708
PMCID:
PMC4629451
DOI:
10.1038/nrn3921
[Indexed for MEDLINE]
Free PMC Article

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