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Breast Cancer Res. 2015 Jul 16;17:95. doi: 10.1186/s13058-015-0601-4.

Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.

Author information

1
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. kbertran@hsph.harvard.edu.
2
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. kbertran@hsph.harvard.edu.
3
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. hbaer@partners.org.
4
Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02120, USA. hbaer@partners.org.
5
Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02120, USA. eorav@partners.org.
6
Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. eorav@partners.org.
7
Dangeard Group, 740 chemin de la Commanderie St Jean de Malte, 13080, Luynes, France. catherine@dangeard.com.
8
Department of Radiology, University of California, 505 Parnassus Avenue, San Francisco, CA, 94143, USA. john.shepherd@ucsf.edu.
9
Department of Preventive Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL, 60611, USA. lvanhorn@northwestern.edu.
10
Department of Epidemiology, University of Iowa College of Public Health, 145 North Riverside Drive, Iowa City, IA, 52242, USA. linda-snetselaar@uiowa.edu.
11
Kaiser Permanente Center for Health Research, 3800 North Interstate Avenue, Portland, OR, 97227, USA. Victor.J.Stevens@kpchr.org.
12
Department of Radiology, University of California, 505 Parnassus Avenue, San Francisco, CA, 94143, USA. Nola.Hylton@ucsf.edu.
13
Department of Epidemiology and Public Health, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA. JDorgan@som.umaryland.edu.

Abstract

INTRODUCTION:

Overweight and obesity in childhood and adolescence are associated with reduced breast cancer risk, independent of adult body mass index (BMI). These associations may be mediated through breast density.

METHODS:

We prospectively examined associations of early life body fatness with adult breast density measured by MRI in 182 women in the Dietary Intervention Study in Children (DISC) who were ages 25-29 at follow-up. Height, weight, and other factors were measured at baseline (ages 8-10) and annual clinic visits through adolescence. We used linear mixed-effects models to quantify associations of percent breast density and dense and non-dense breast volume at ages 25-29 with quartiles of age-specific youth body mass index (BMI) Z-scores, adjusting for clinic, treatment group, current adult BMI, and other well-established risk factors for breast cancer and predictors of breast density.

RESULTS:

We observed inverse associations between age-specific BMI Z-scores at all youth clinic visits and percent breast density, adjusting for current adult BMI and other covariates (all p values <0.01). Women whose baseline BMI Z-scores (at ages 8-10 years) were in the top quartile had significantly lower adult breast density, after adjusting for current adult BMI and other covariates [least squares mean (LSM): 23.4 %; 95 % confidence interval (CI): 18.0 %, 28.8 %] compared to those in the bottom quartile (LSM: 31.8 %; 95 % CI: 25.2 %, 38.4 %) (p trend <0.01). Significant inverse associations were also observed for absolute dense breast volume (all p values <0.01), whereas there were no clear associations with non-dense breast volume.

CONCLUSIONS:

These results support the hypothesis that body fatness during childhood and adolescence may play an important role in premenopausal breast density, independent of current BMI, and further suggest direct or indirect influences on absolute dense breast volume.

CLINICAL TRIALS REGISTRATION NUMBER:

NCT00458588 ; April 9, 2007.

PMID:
26174168
PMCID:
PMC4502611
DOI:
10.1186/s13058-015-0601-4
[Indexed for MEDLINE]
Free PMC Article

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