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IUBMB Life. 2015 Jul;67(7):472-81. doi: 10.1002/iub.1395. Epub 2015 Jul 14.

The Groucho/Transducin-like enhancer of split protein family in animal development.

Author information

1
Regional Centre for Biotechnology, NCR Bio-Science Cluster, Faridabad, Haryana, India.

Abstract

Corepressors are proteins that cannot bind DNA directly but repress transcription by interacting with partner proteins. The Groucho/Transducin-Like Enhancer of Split (TLE) are a conserved family of corepressor proteins present in animals ranging from invertebrates such as Drosophila to vertebrates such as mice and humans. Groucho/TLE proteins perform important functions throughout the life span of animals, interacting with several pathways and regulating fundamental processes such as metabolism. However, these proteins have especially crucial functions in animal development, where they are required in multiple tissues in a temporally regulated manner. In this review, we summarize the functions of the Groucho/TLE proteins during animal development, emphasizing on specific tissues where they play essential roles.

KEYWORDS:

corepressor; development; groucho; homeobox genes; transcription factor; transducin-like enhancer of split (TLE)

PMID:
26172616
DOI:
10.1002/iub.1395
[Indexed for MEDLINE]
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