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PLoS One. 2015 Jul 14;10(7):e0131965. doi: 10.1371/journal.pone.0131965. eCollection 2015.

Survival and Cause of Death among a Cohort of Confirmed Amyotrophic Lateral Sclerosis Cases.

Author information

1
California Environmental Health Tracking Program, Public Health Institute, Richmond, California, United States of America.
2
California Environmental Health Tracking Program, California Department of Public Health, Richmond, California, United States of America.
3
McKing Consulting Corporation. Atlanta, Georgia, United States of America.

Abstract

INTRODUCTION:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Estimates of survival from disease onset range from 20 to 48 months and have been generated using clinical populations or death records alone.

METHODS:

Data on a cohort of ALS cases diagnosed between 2009-2011 were collected as part of the Los Angeles and San Francisco Bay Area Metropolitan ALS Surveillance projects; death records 2009-2013 were linked to these confirmed cases to determine survival post diagnosis and factors associated with survival time.

RESULTS:

There were 618 cases identified and 283 of these died during the follow up time period. Median age at death was 64.3 years, and median survival time post-diagnosis was 2.6 years. Age at diagnosis and year of diagnosis were predictors of survival time in adjusted models; those diagnosed at age 80 or older had shorter survival than those diagnosed at age 50 or younger. Most (92%) had ALS noted as a cause of death.

DISCUSSION:

Survival post-diagnosis may be improved compared with previous reports. Age at diagnosis continues to be the strongest predictor of prognosis; recall case reporting bias may play a role in estimates of survival time.

PMID:
26172548
PMCID:
PMC4501568
DOI:
10.1371/journal.pone.0131965
[Indexed for MEDLINE]
Free PMC Article

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