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Iran J Public Health. 2014 Dec;43(12):1651-6.

The Effects of Vitamin D Supplementation on Glucose Control and Insulin Resistance in Patients with Diabetes Type 2: A Randomized Clinical Trial Study.

Author information

1
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences And Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
2
Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
3
Dept. of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Vitamin D deficiency is prevalent in diabetes type 2 and this vitamin may be related to insulin action. This randomized controlled trial study was done to evaluate the effect of vitamin D supplementation on glucose control and insulin resistance in patients with diabetes type 2.

METHODS:

Participants of this randomized clinical trial study consisted of 28 patients with type 2 diabetes who received 100 microgram (4000 IU) vitamin D and 30 diabetic patients who received placebo for 2 months between September 2012 and February 2013. The effect of vitamin D on glucose control was assessed by measuring HbA1c and insulin resistance as HOMA-IR at the baseline and the end of the intervention.

RESULTS:

The results showed a significant decrease in HbA1c (from 7.29 ± 0.22 % to 6.76 ± 0.18 %, P<0.001) and insulin concentration (from 8.24 ± 0.97 μIU/mL to 6.55 ± 0.28 μIU/mL, P=0.048), but a non-significant decrease in HOMA-IR in vitamin D group. Also, HDL-C level increased significantly in both of vitamin D (P=0.046) and placebo groups (P=0.028).

CONCLUSION:

It seems that vitamin D supplementation has beneficial effects on glucose homeostasis and can increases insulin sensitivity in diabetic 2 patients.

KEYWORDS:

Diabetes type 2; HbA1c; Insulin resistance; Vitamin D

PMID:
26171357
PMCID:
PMC4499086

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