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Exp Ther Med. 2015 Jul;10(1):247-250. Epub 2015 May 19.

Acaricidal activity of extracts from Ligularia virgaurea against the Sarcoptes scabiei mite in vitro.

Author information

1
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan 611130, P.R. China.
2
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan 611130, P.R. China ; Qiandongnan Prefectural Center for Animal Disease Control and Prevention, Kaili, Guizhou 556000, P.R. China.
3
Ganzi Institute of Animal Husbandary, Kangding, Sichuan 626000, P.R. China.
4
Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Science, Northwest University, Xi'an, Shaanxi 710069, P.R. China.

Abstract

The aim of the present study was to investigate the acaricidal activity of Ligularia virgaurea. An extract was prepared by refluxing with ethanol and steam distillation, and its toxic effect was tested in vitro against Sarcoptes scabiei. The data from the toxicity tests were analyzed using a complementary log-log (CLL) model. The ethanol extract exhibited strong acaricidal activity against these mites; at a concentration of 2 g/ml it killed all S. scabiei within 2 h and at 1 g/ml it killed all S. scabiei within 6 h. Similarly, 2, 1, 0.5 and 0.25 g/ml concentrations of the extract had strong toxicity against S. scabiei, with median lethal time (LT50) values of 0.716, 1.741, 2.968 and 4.838 h, respectively. The median lethal concentration (LC50) values were 1.388, 0.624, 0.310 and 0.213 g/ml for Scabies mite in 1, 2, 4 and 6 h, respectively. The results indicate that the L. virgaurea extract has strong acaricidal activity and may be exploited as a novel treatment for the effective control of acariasis in animals.

KEYWORDS:

Ligularia virgaurea; Sarcoptes scabiei; acaricidal activity; toxic effect

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