Format

Send to

Choose Destination
Am J Kidney Dis. 2015 Oct;66(4):699-709. doi: 10.1053/j.ajkd.2015.05.021. Epub 2015 Jul 11.

Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy.

Author information

1
Department of Microbiology and Immunology, Laboratory of Abdominal Transplantation, KU Leuven, University of Leuven, Leuven, Belgium; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium. Electronic address: jeanpaul.decuypere@med.kuleuven.be.
2
Department of Microbiology and Immunology, Laboratory of Abdominal Transplantation, KU Leuven, University of Leuven, Leuven, Belgium; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
3
Department of Cellular and Molecular Medicine, Laboratory of Cell Death Research and Therapy, Leuven, Belgium.
4
Department of Microbiology and Immunology, Laboratory of Nephrology, KU Leuven, University of Leuven, Leuven, Belgium; Department of Nephrology, University Hospitals Leuven, Leuven, Belgium.

Abstract

Autophagy, an evolutionary conserved intracellular lysosome-dependent catabolic process, is an important mechanism for cellular homeostasis and survival during pathologic stress conditions in the kidney, such as ischemia-reperfusion injury (IRI). However, stimulation of autophagy has been described to both improve and exacerbate IRI in the kidney. We summarize the current understanding of autophagy in renal IRI and discuss possible reasons for these contradictory findings. Furthermore, we hypothesize that autophagy plays a dual role in renal IRI, having both protective and detrimental properties, depending on the duration of the ischemic period and the phase of the IRI process. Finally, we discuss the influence of currently used diuretics and immunosuppressive drugs on autophagy, underscoring the need to clarify the puzzling role of autophagy in renal IRI.

KEYWORDS:

Autophagy; acute kidney injury (AKI); animal model; cell death; delayed graft function; immunosuppression; ischemia-reperfusion injury (IRI); kidney transplantation; macroautophagy; renal IRI; review; stress response

PMID:
26169721
DOI:
10.1053/j.ajkd.2015.05.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center