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Arch Virol. 2015 Oct;160(10):2569-75. doi: 10.1007/s00705-015-2523-y. Epub 2015 Jul 14.

Rabovirus: a proposed new picornavirus genus that is phylogenetically basal to enteroviruses and sapeloviruses.

Author information

1
Blood Systems Research Institute, San Francisco, CA, USA. terryfeifan@gmail.com.
2
Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA. terryfeifan@gmail.com.
3
DVD, NCIRD, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA, 30333, USA. terryfeifan@gmail.com.
4
Blood Systems Research Institute, San Francisco, CA, USA.
5
Federal Institute for Risk Assessment, Berlin, Germany.
6
Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary.
7
The Pirbright Institute, Woking, Surrey, UK.
8
Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA.

Abstract

We have sequenced the genome of a novel picornavirus, rabovirus A (rat-borne virus, RaBoV-A, NC_026314), which was present in the feces of a Norway rat (Rattus norvegicus) from Berlin, Germany. This virus is related to members of the genera Enterovirus and Sapelovirus. RaboV-A contains a type II IRES that is unlike the type I IRES elements of enteroviruses and the type IV elements of sapeloviruses. Its genome is marked by an L protein and a chymotrypsin-like 2A protease. Our analysis of genome organization, pairwise identities, motif, phylogenic and UTR (GIMPU) indicates that RaBoV-A potentially represents a new picornavirus genus, for which we propose the name "Rabovirus". Spread by their rodent hosts and detected in New York and Berlin rats, these viruses may have a wide geographic distribution.

PMID:
26168710
DOI:
10.1007/s00705-015-2523-y
[Indexed for MEDLINE]

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