Format

Send to

Choose Destination
Anticancer Res. 2015 Aug;35(8):4403-10.

Analysis of Wnt and β-catenin Expression in Advanced Colorectal Cancer.

Author information

1
Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
2
Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan kinugasa_tetsushi@med.kurume-u.ac.jp.
3
Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.

Abstract

BACKGROUND:

Wnt/β-catenin signaling plays an important role in colorectal cancer (CRC). Wnt has many sub-types and it is uncertain which of them affect progression of CRC.

PATIENTS AND METHODS:

We analysed 201 patients who underwent curative surgery for CRC. We investigated the relationship between the expression of Wnt and β-catenin proteins and prognosis using immunohistochemistry.

RESULTS:

The high expression of Wnt1 correlated with high expression of nuclear and cytoplasmic β-catenin (p=0.0004, p=0.02). The high expression of Wnt5a also correlated with high expression of membrane β-catenin (p=0.03). In multivariate analysis, lymph node metastasis (p=0.046) and high expression of nuclear β-catenin (p=0.04) were independent prognostic factors for survival.

CONCLUSION:

The expression of nuclear β-catenin is a useful predictive marker in CRC. It is suggested that Wnt1 may be the main activator of the β-catenin signaling pathway and that Wnt5a may stabilize adherens junctions, thereby suppressing the epithelial-mesenchymal transition.

KEYWORDS:

Wnt; colorectal cancer; β-catenin

PMID:
26168479
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center