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Nat Neurosci. 2015 Aug;18(8):1168-74. doi: 10.1038/nn.4063. Epub 2015 Jul 13.

Coexpression networks identify brain region-specific enhancer RNAs in the human brain.

Author information

1
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
2
QFAB Bioinformatics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.

Abstract

Despite major progress in identifying enhancer regions on a genome-wide scale, the majority of available data are limited to model organisms and human transformed cell lines. We have identified a robust set of enhancer RNAs (eRNAs) expressed in the human brain and constructed networks assessing eRNA-gene coexpression interactions across human fetal brain and multiple adult brain regions. Our data identify brain region-specific eRNAs and show that enhancer regions expressing eRNAs are enriched for genetic variants associated with autism spectrum disorders.

PMID:
26167905
DOI:
10.1038/nn.4063
[Indexed for MEDLINE]

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