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Nat Struct Mol Biol. 2015 Aug;22(8):642-4. doi: 10.1038/nsmb.3054. Epub 2015 Jul 13.

The molecular basis for flexibility in the flexible filamentous plant viruses.

Author information

1
Department of Biochemistry, University of Washington, Seattle, Washington, USA.
2
1] Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan. [2] Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan. [3] Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan.
3
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.
4
Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan.
5
1] Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan. [2] Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan. [3] Biotechnology Center, National Chung-Hsing University, Taichung, Taiwan.

Abstract

Flexible filamentous plant viruses cause more than half the viral crop damage in the world but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed, owing to the virion's extreme flexibility. We have used cryo-EM to generate an atomic model for bamboo mosaic virus, which reveals flexible N- and C-terminal extensions that allow deformation while still maintaining structural integrity.

PMID:
26167882
PMCID:
PMC4527879
DOI:
10.1038/nsmb.3054
[Indexed for MEDLINE]
Free PMC Article

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