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Biomed Res Int. 2015;2015:604385. doi: 10.1155/2015/604385. Epub 2015 Jun 17.

Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

Author information

1
College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da' an District, Taipei City 10617, Taiwan.
2
Department of Research and Development, Super Beta Glucan Inc., Irvine, CA, USA.
3
Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Abstract

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.

PMID:
26167490
PMCID:
PMC4488085
DOI:
10.1155/2015/604385
[Indexed for MEDLINE]
Free PMC Article

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