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Adipocyte. 2014 Dec 17;4(2):158-60. doi: 10.4161/21623945.2014.973774. eCollection 2015 Apr-Jun.

Adipocyte size fluctuation, mechano-active lipid droplets and caveolae.

Author information

1
INSERM SOPAM; U1063; Université d'Angers; IBS-IRIS Rue des Capucins ; Angers, France.
2
INSERM; UMRS 938; Center de Recherche Saint-Antoine ; Paris, France.
3
INSERM; UMRS U1166; Nutriomics team 6 ; Paris, France ; Sorbonne Universités; UPMC Univ Paris 06; UMRS 1166 ; Paris, France.

Abstract

Recent data indicate that cell size fluctuation, a key property in adipocyte pathophysiology primarily dependent on lipid storage, is linked to a novel function of lipid droplet organelles acting as mechano-active organelles to regulate cell membrane remodeling and caveolae dynamics.

KEYWORDS:

Caveolae; cell size; lipid droplets; lipolysis; membrane; stretch

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