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Parkinsons Dis. 2015;2015:461453. doi: 10.1155/2015/461453. Epub 2015 Jun 18.

Self-Reported Executive Functioning in Everyday Life in Parkinson's Disease after Three Months of Subthalamic Deep Brain Stimulation.

Author information

1
Department of Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway ; Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.
2
Department of Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway ; Department of Psychology, University of Oslo, 0316 Oslo, Norway.
3
Department of Neurology, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway.
4
Oslo Centre of Biostatistics and Epidemiology, Oslo University Hospital, 0424 Oslo, Norway.
5
Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway.
6
Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway ; Department of Neurology, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway.
7
Department of Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway.
8
Department of Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway ; Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, 0424 Oslo, Norway ; Department of Neuropsychology, Helgeland Hospital, 8607 Mosj√łen, Norway.

Abstract

OBJECTIVE:

Studies on the effect of subthalamic deep brain stimulation (STN-DBS) on executive functioning in Parkinson's disease (PD) are still controversial. In this study we compared self-reported daily executive functioning in PD patients before and after three months of STN-DBS. We also examined whether executive functioning in everyday life was associated with motor symptoms, apathy, and psychiatric symptoms.

METHOD:

40 PD patients were examined with the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), the Symptom Checklist 90-Revised (SCL-90-R), and the Apathy Evaluation Scale (AES-S).

RESULTS:

PD patients reported significant improvement in daily life executive functioning after 3 months of STN-DBS. Anxiety scores significantly declined, while other psychiatric symptoms remained unchanged. The improvement of self-reported executive functioning did not correlate with motor improvement after STN-DBS. Apathy scores remained unchanged after surgery. Only preoperative depressed mood had predictive value to the improvement of executive function and appears to prevent potentially favorable outcomes from STN-DBS on some aspects of executive function.

CONCLUSION:

PD patients being screened for STN-DBS surgery should be evaluated with regard to self-reported executive functioning. Depressive symptoms in presurgical PD patients should be treated. Complementary information about daily life executive functioning in PD patients might enhance further treatment planning of STN-DBS.

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