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Oxid Med Cell Longev. 2015;2015:201843. doi: 10.1155/2015/201843. Epub 2015 Jun 17.

Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

Author information

1
PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France ; Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.
2
PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France ; Department of Clinical Physiology, CHRU Montpellier, 34295 Montpellier, France.
3
Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.
4
Department of Cardiovascular Surgery and CREDEC, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.
5
PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France.
6
University of Montpellier, 34295 Montpellier, France ; Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.

Abstract

Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.

PMID:
26167238
PMCID:
PMC4488160
DOI:
10.1155/2015/201843
[Indexed for MEDLINE]
Free PMC Article

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