Format

Send to

Choose Destination
J Ayurveda Integr Med. 2015 Apr-Jun;6(2):82-8. doi: 10.4103/0975-9476.146540.

Effect of Jyotishmati (Celastrus paniculatus) seeds in animal models of pain and inflammation.

Author information

1
Department of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India.

Abstract

BACKGROUND:

Jyotishmati, scientifically known as Celastrus paniculatus Wild (Celastraceae) is one of the most important medicinal plants in Ayurveda. The plant has shown significant pharmacological activities like anti-arthritic, wound healing, hypolipidemic, and antioxidant.

OBJECTIVE:

To study possible effects of alcoholic extract of Celastrus paniculatus seeds (AlcE) in experimentally induced pain and inflammation in mice.

MATERIALS AND METHODS:

The antinociceptive activity was evaluated in Swiss albino mice by tail immersion, hot plate, and acetic-acid-induced writhing tests at doses of 250, 500, and 1,000 mg/kg. Anti-inflammatory activity was evaluated in model of carrageenan-induced acute plantar inflammation in Wistar rats.

RESULTS:

In tail immersion test, AlcE showed significant (P < 0.05) increase in tail withdrawal response at dose of 250 mg/kg with maximum possible effect of 15.71%. The maximum possible effect of 23.32% and 30.16% (P < 0.001) was seen at dose of 500 and 1000 mg/kg at 3 hours after administration of extract, respectively. In hot plate test, increase in paw licking time was reported at dose of 500 and 1000 mg/kg. AlcE (1,000 mg/kg) showed maximum response (6.23 ± 0.46) when compared with control (3.20 ± 0.18) at 90 min. In acetic acid induced writhings, AlcE at dose of 250, 500, and 1,000 mg/kg body weight showed 32.35%, 49.01%, and 58.82% inhibition in writhings, respectively. AlcE treated animals (500 and 1,000 mg/kg) showed significant decrease in paw edema at 3 hours and 4 hours, when compared with control animals.

CONCLUSION:

Jyotishmati seed extract possesses significant antinociceptive and anti-inflammatory activity.

KEYWORDS:

Acetic acid; analgesic; anti-inflammatory; carrageenan; hot plate; tail immersion

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center