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Nat Prod Res. 2016;30(10):1178-81. doi: 10.1080/14786419.2015.1043630. Epub 2015 Jul 13.

Antibacterial activity of commercially available plant-derived essential oils against oral pathogenic bacteria.

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a Laboratório de Pesquisa em Microbiologia Aplicada , Universidade de Franca , Av. Dr. Armando Salles de Oliveira, 201 - Parque Universitário, CEP 14404-600, Franca , SP , Brazil.
b Departamento de Química , Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , SP , Brazil.


This work investigated the antibacterial activity of 15 commercially available plant-derived essential oils (EOs) against a panel of oral pathogens. The broth microdilution method afforded the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of the assayed EOs. The EO obtained from Cinnamomum zeylanicum (Lauraceae) (CZ-EO) displayed moderate activity against Fusobacterium nucleatum (MIC and MBC = 125 μg/mL), Actinomyces naeslundii (MIC and MBC = 125 μg/mL), Prevotella nigrescens (MIC and MBC = 125 μg/mL) and Streptococcus mutans (MIC = 200 μg/mL; MBC = 400 μg/mL). (Z)-isosafrole (85.3%) was the main chemical component of this oil. We did not detect cinnamaldehyde, previously described as the major constituent of CZ-EO, in specimens collected in other countries.


Cinnamomum zeylanicum; Streptococcus mutans; cariogenic bacteria

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