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J Microbiol Biotechnol. 2015 Oct;25(10):1697-701. doi: 10.4014/jmb.1503.03033.

Anticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34.

Author information

1
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Republic of Korea.
2
Department of Food Science, Sun Moon University, Asan 336-708, Republic of Korea.
3
Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Republic of Korea.

Abstract

The anticancer and anti-inflammatory activities of probiotic Lactococcus lactis NK34 were demonstrated. Treatment of cancer cells such as SK-MES-1, DLD-1, HT-29, LoVo, AGS, and MCF-7 cells with 10(6) CFU/well of L. lactis NK34 resulted in strong inhibition of proliferation (>77% cytotoxicity, p < 0.05). The anti-inflammatory activity of L. lactis NK34 was also demonstrated in lipopolysaccharide-induced RAW 264.7 cells, where the production of nitric oxide and proinflammatory cytokines (tumor necrosis factor-α, interleukin-18, and cyclooxygenase-2) was reduced. These results suggest that L. lactis NK34 could be used as a probiotic microorganism to inhibit the proliferation of cancer cells and production of proinflammatory cytokines.

KEYWORDS:

Lactococcus lactis; Probiotic; anti-inflammatory activity; anticancer activity; cytokine

PMID:
26165315
DOI:
10.4014/jmb.1503.03033
[Indexed for MEDLINE]
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