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Am J Ophthalmol. 2015 Oct;160(4):749-58.e1. doi: 10.1016/j.ajo.2015.07.004. Epub 2015 Jul 8.

Spectral-Domain Optical Coherence Tomography of Subretinal Hyperreflective Exudation in Myopic Choroidal Neovascularization.

Author information

1
Centre Hospitalier Intercommunal de Créteil, CRC, Paris Est Créteil University, Créteil, France.
2
Centre Hospitalier Intercommunal de Créteil, CRC, Paris Est Créteil University, Créteil, France. Electronic address: eric.souied@chicreteil.fr.

Abstract

PURPOSE:

To study the effect of anti-vascular endothelial growth factor (VEGF) therapy on subretinal hyperreflective exudation detected by spectral-domain optical coherence tomography (SD OCT) in myopic choroidal neovascularization (CNV).

DESIGN:

Retrospective consecutive observational cohort study.

METHODS:

Thirty-one eyes of 31 consecutive highly myopic patients with CNV and showing a subretinal hyperreflective exudation on SD OCT were included. Morphologic changes were assessed before and after anti-VEGF therapy, based on the subretinal hyperreflective exudation thickness, retinal thickness at the level of the CNV, and central macular thickness.

RESULTS:

After anti-VEGF treatment (mean follow-up of 1.9 ± 0.8 months, mean number of injections 1.8 ± 0.6), the subretinal hyperreflective exudation regressed completely in 29 of 31 eyes (93.5%) and partially in 2 of 31 eyes (6.5%). Mean subretinal hyperreflective exudation thickness, mean retinal thickness at the level of the CNV, and mean central macular thickness significantly decreased from 102 ± 50 μm to 2.6 ± 10.2 μm (P < .0001), from 419 ± 99 μm to 312 ± 64 μm (P < .0001), and from 361 ± 69 μm to 326 ± 72 μm (P = .0008), respectively.

CONCLUSION:

The subretinal hyperreflective exudation was an SD OCT finding that correlated with signs of active myopic CNV (either subretinal fluid/intraretinal cysts on SD OCT or dye leakage on fluorescein angiography) and responded to treatment with anti-VEGF agents. The presence of a subretinal hyperreflective exudation on SD OCT could help in making decisions on the need to perform or not perform fluorescein angiography, and regarding treatment or retreatment.

PMID:
26164828
DOI:
10.1016/j.ajo.2015.07.004
[Indexed for MEDLINE]

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