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Eur J Pharmacol. 2016 May 5;778:2-10. doi: 10.1016/j.ejphar.2015.07.016. Epub 2015 Jul 8.

Murine and human mast cell progenitors.

Author information

1
Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
2
Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: frank.siebenhaar@charite.de.

Abstract

The development of mature mast cells (MCs) from hematopoietic progenitor cells as well as the identification and characterization of committed progenitor cells are a current focus of mast cell research. Most published reports in this area are on the origin and differentiation of MCs in mice. Evidence for the human system, i.e. derived from primary human MCs, is widely lacking. Based on the published data, MCs develop either from a committed progenitor or from a common basophil/mast cell precursor. This review summarizes the current knowledge on MC development and MC differentiation.

KEYWORDS:

Development; Differentiation; HSC; Mast cell; Progenitor

PMID:
26164789
DOI:
10.1016/j.ejphar.2015.07.016
[Indexed for MEDLINE]

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