Format

Send to

Choose Destination
Inflamm Bowel Dis. 2015 Aug;21(8):1967-75. doi: 10.1097/MIB.0000000000000468.

A Multihit Model: Colitis Lessons from the Interleukin-10-deficient Mouse.

Author information

1
Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.

Abstract

Complex mechanisms are pulling the strings to initiate the development of inflammatory bowel disease. Current evidence indicates that an interaction of genetic susceptibilities (polymorphisms), environmental factors, and the host microbiota leads to a dysregulation of the mucosal immune system. In the past decades, the interleukin-10-deficient mouse has served as an excellent model to mirror the multifactorial nature of this disease. Here, we want to review in detail the interplay of the genetic factors, immune aspects, and especially summarize and discuss the role of the microbiota contributing to colitis development in the interleukin-10-deficient mouse model of inflammatory bowel disease as a multihit model.

PMID:
26164667
PMCID:
PMC4511684
DOI:
10.1097/MIB.0000000000000468
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center