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J Colloid Interface Sci. 2015 Nov 1;457:152-61. doi: 10.1016/j.jcis.2015.06.010. Epub 2015 Jun 17.

Development of pharmaceutical clear gel based on Peceol®, lecithin, ethanol and water: Physicochemical characterization and stability study.

Author information

1
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France; Medesis Pharma, S.A, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
2
Institut de chimie séparative de Marcoule, ICSM UMR 5257 (CEA/CNRS/UM2/ENSCM), 30206 Bagnols sur Cèze, France.
3
Institut des biomolécules Max Mousseron, UMR CNRS 5247, Université de Montpellier I, 34060 Montpellier, France.
4
Centre de Recherche Paul Pascal (CRPP), CNRS, 115 av. Schweitzer, F-33600 Pessac, France.
5
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France.
6
Medesis Pharma, S.A, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
7
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France. Electronic address: philippe.legrand@univ-montp1.fr.

Abstract

The phase behavior of the four-components Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol® ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex systems were identified. W/O microemulsion (L2) as well as an inverted hexagonal (H2) liquid-crystal phase were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this clear gel and to show its pharmaceutical interest among lecithin organogels.

KEYWORDS:

Gel; Inverted hexagonal phase; Lecithin; Mono- di- tri-glycerides; Phase diagram; Polar lipids; W/O microemulsion

PMID:
26164247
DOI:
10.1016/j.jcis.2015.06.010
[Indexed for MEDLINE]

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