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Drug Alcohol Depend. 2015 Sep 1;154:167-73. doi: 10.1016/j.drugalcdep.2015.06.039. Epub 2015 Jun 30.

A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.

Author information

  • 1Department of Diagnostic Radiology, Yale University, New Haven, CT, United States; Department of Psychiatry, Yale University, New Haven, CT, United States. Electronic address: david.matuskey@yale.edu.
  • 2Department of Diagnostic Radiology, Yale University, New Haven, CT, United States; Department of Psychiatry, Yale University, New Haven, CT, United States.
  • 3Department of Diagnostic Radiology, Yale University, New Haven, CT, United States.
  • 4Department of Psychiatry, Yale University, New Haven, CT, United States.
  • 5Department of Radiology, New York University School of Medicine, New York, NY, United States; Department of Psychiatry, New York University School of Medicine, New York, NY, United States.
  • 6Department of Psychiatry, Yale University, New Haven, CT, United States; Department of Neurobiology, Yale University, New Haven, CT, United States; Department of Child Study Center, Yale University, New Haven, CT, United States.

Abstract

BACKGROUND:

Previous work in healthy non-human primates and humans has shown that social status correlates positively with dopamine 2/3 receptor (D2/3R) availability imaged with antagonist radioligands and positron emission tomography (PET). Further work in non-human primates suggests that this relationship is disrupted by chronic cocaine administration. This exploratory study examined the relationship between social status and D2/3R availability in healthy (HH) and cocaine dependent (CD) humans using the D3-preferring, agonist radioligand, [(11)C](+)PHNO.

METHODS:

Sixteen HH and sixteen CD individuals completed the Barratt Simplified Measure of Social Status (BSMSS) and underwent [(11)C](+)PHNO scanning to measure regional brain D2/3R binding potentials (BPND). Correlations between BPND and BSMSS scores were then assessed within each group.

RESULTS:

Within HH and CD groups, inverse associations between BSMSS score and BPND were observed in the substantia nigra/ventral tegmental area (SN/VTA) and the ventral striatum, and for the CD group alone, the amygdala. After adjusting for body mass index and age, negative correlations remained significant in the SN/VTA for HH and in the amygdala for CD subjects.

CONCLUSION:

These preliminary data utilizing a dopamine agonist tracer demonstrate, for the first time, an inverse association between social status and D2/3R availability in the D3R rich extrastriatal regions of HH and CD humans.

KEYWORDS:

Cocaine; Dopamine; PET imaging; Social status; [(11)C](+)PHNO

PMID:
26164205
PMCID:
PMC4536182
DOI:
10.1016/j.drugalcdep.2015.06.039
[PubMed - indexed for MEDLINE]
Free PMC Article
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