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Brain Imaging Behav. 2016 Jun;10(2):506-16. doi: 10.1007/s11682-015-9427-z.

Intra-regional and inter-regional abnormalities and cognitive control deficits in young adult smokers.

Feng D1,2, Yuan K3,4, Li Y1,2, Cai C1,2, Yin J1,2, Bi Y1,2, Cheng J1,2, Guan Y1,2, Shi S1,2, Yu D5, Jin C6, Lu X7, Qin W1,2, Tian J1,2,8.

Author information

1
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China.
2
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
3
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China. 119829640@qq.com.
4
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China. 119829640@qq.com.
5
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. fmydh@imust.edu.cn.
6
Department of Medical Imaging, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
7
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China.
8
Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.

Abstract

Tobacco use during later adolescence and young adulthood may cause serious neurophysiological changes; rationally, it is extremely important to study the relationship between brain dysfunction and behavioral performances in young adult smokers. Previous resting state studies investigated the neural mechanisms in smokers. Unfortunately, few studies focused on spontaneous activity differences between young adult smokers and nonsmokers from both intra-regional and inter-regional levels, less is known about the association between resting state abnormalities and behavioral deficits. Therefore, we used fractional amplitude of low frequency fluctuation (fALFF) and resting state functional connectivity (RSFC) to investigate the resting state spontaneous activity differences between young adult smokers and nonsmokers. A correlation analysis was carried out to assess the relationship between neuroimaging findings and clinical information (pack-years, cigarette dependence, age of onset and craving score) as well as cognitive control deficits measured by the Stroop task. Consistent with previous addiction findings, our results revealed the resting state abnormalities within frontostriatal circuits, i.e., enhanced spontaneous activity of the caudate and reduced functional strength between the caudate and anterior cingulate cortex (ACC) in young adult smokers. Moreover, the fALFF values of the caudate were correlated with craving and RSFC strength between the caudate and ACC was associated with the cognitive control impairments in young adult smokers. Our findings could lead to a better understanding of intrinsic functional architecture of baseline brain activity in young smokers by providing regional and brain circuit spontaneous neuronal activity properties as well as their association with cognitive control impairments.

KEYWORDS:

Anterior cingulate cortex; Caudate; Cognitive control; Fractional amplitude of low frequency fluctuation; Resting state functional connectivity; Young adult smokers

PMID:
26164168
DOI:
10.1007/s11682-015-9427-z
[Indexed for MEDLINE]

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